Endocrine Abstracts

Spermatozoa generate small amounts of O2°- and NO°. Under physiological condition these compounds exist at very low concentration and the formation of peroxynitrite (ONOO−) appears likely. Peroxynitrite reacts rapidly with proteins, lipids and DNA. Moreover, tyrosine nitration is a widely used marker of peroxynitrite. The nitration of protein residues gives rise to 3-nitrotyrosine which represents a protein modification specific for ONOO− formation in ...

Objective(S): Single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (eNOS) G894T may affect the oxidative stress response. Our objective was to examine G894T SNP eNOS genotype frequencies and its potential role with sperm motility in infertile men. Through this prospective controlled study in the Andrology Unit, we have enrolled infertile (n=70) and healthy (n=60) men. Sperm motion kinetics assessed by computer assisted semen analysis (CASA), ...